TJHSST’s Legacy in the Regeneron Science Talent Search (STS) and ISEF

Thomas Jefferson High School for Science and Technology (TJHSST) has long been a powerhouse in national and international science competitions, particularly the Regeneron Science Talent Search (STS) and the Regeneron International Science and Engineering Fair (ISEF). Year after year, TJ students continue to achieve remarkable success, solidifying the school’s reputation as one of the country’s top STEM institutions.

2025 Regeneron STS: TJ’s Continued Excellence

This year, eight TJHSST students were named scholars in the prestigious 2025 Regeneron Science Talent Search, which recognizes the top young scientists in the country. Among them, Ray Zhang was selected as a finalist for his research on developing a multi-targeted antifungal treatment—an achievement that highlights the advanced scientific inquiry taking place at TJ.

TJHSST’s dominance in STS is a reflection of its strong research culture and the breadth of scientific fields that students engage in. Projects from this year’s scholars span areas such as quantum computing, synthetic biology, bioinformatics, and astrophysics, showcasing the diversity of innovation fostered at the school.

A History of STS Success

TJHSST’s performance in STS is not a one-time event. Over the years, TJ has consistently had multiple students named semifinalists and finalists, reinforcing the school’s ability to foster independent research at a high level. Past TJ students like David Lu Cao (2024 finalist) have earned national recognition for their innovative projects, ranging from biomedical engineering to artificial intelligence.

In 2023, TJ had nine STS scholars, and in previous years, the school has had as many as 14 students recognized in a single cycle. This long-standing success speaks to TJ’s investment in research infrastructure and student mentorship, both of which play a crucial role in helping students develop competitive projects.

TJ’s Strength at ISEF

Beyond STS, TJHSST students also dominate at the Regeneron International Science and Engineering Fair (ISEF). Each year, multiple TJ students qualify through regional competitions, often winning top awards in categories like Computational Biology, Engineering, and Physics. This global competition provides TJ students with an opportunity to showcase their research on an international stage.

At ISEF 2024, TJHSST students took home several major awards, including Grand Awards in Physics and Astronomy, as well as special industry prizes from research organizations. Some TJ students also earned opportunities for summer internships and university collaborations as a result of their ISEF projects.

Why Is TJ So Successful in STS and ISEF?

Several factors contribute to TJ’s dominance in elite science competitions:

• Senior Research Labs: TJ offers specialized research opportunities in areas like neuroscience, quantum physics, and artificial intelligence, allowing students to conduct projects at a level far beyond typical high school research.

• Strong Faculty Mentorship: Teachers and research coordinators at TJ help students refine their projects and connect with professional labs.

• A Culture of Scientific Inquiry: TJ fosters an environment where students are encouraged to push the boundaries of knowledge, whether in biology, engineering, or computer science.

• Access to High-Level Resources: Students have access to cutting-edge lab equipment, university collaborations, and research-grade software, enabling them to work on projects that can compete at national and international levels.

  
  

Looking Ahead

With TJHSST’s continued success in STS and ISEF, the school remains a breeding ground for the next generation of scientists, engineers, and innovators. Future students will undoubtedly follow in the footsteps of past winners, keeping TJ at the forefront of high school research excellence.

As the 2025 STS and ISEF competitions progress, all eyes will be on TJ’s young researchers as they aim for even greater achievements on the national and international stage. The school’s commitment to research, mentorship, and scientific discovery ensures that its students will remain at the cutting edge of innovation for years to come.